Ivabradine (Corlanor) – Mixed Results in Clinical Trials

The next issue of The Medical Letter (1469; May 25, 2015) will include an article on ivabradine (Corlanor – Amgen), a new drug for treatment of heart failure. The FDA-approved indication for its use is actually much more complicated. It specifies that the drug is approved to reduce the risk of hospitalization for worsening heart […]

Interferon Beta for Multiple Sclerosis

The next issue of The Medical Letter (May 11, 2015) will include an article on a new pegylated formulation of interferon beta-1a (Plegridy) recently marketed for treatment of multiple sclerosis (MS). Interferon beta or glatiramer acetate (Copaxone) is generally used first to treat patients with relapsing-remitting MS, but both must be injected: daily with Copaxone […]

Take Our Advice

The April 13, 2015 issue of The Medical Letter includes an article on Advice for Travelers that should be especially useful to our readers and their patients. In just 6 pages, we offer a wealth of information on the prevention and treatment of the common maladies that can spoil a trip, or worse. Travelers’ diarrhea […]

Treating ADHD

The current issue of The Medical Letter leads off with an article on Drugs for ADHD, a disorder once diagnosed only in children, but now recognized in adults as well. It has been estimated that about 5% of all the school children in the western world, mostly boys, fit the criteria for attention-deficit/hyperactivity disorder. In […]

Suvorexant (Belsomra) for Insomnia: One Difficult Sentence

The next issue of The Medical Letter (March 2, 2015) leads off with an article on a new drug with a new mechanism of action for treatment of insomnia. Suvorexant (Belsomra – Merck) is the first orexin receptor antagonist. Signaling of orexin neuropeptides sustains wakefulness; suvorexant promotes sleep by blocking orexin neuropeptides from binding to […]

Lifestyle Intervention for Weight Loss

According to a recent Gallup poll, 36% of US adults believe that they are overweight, and 26% are actively trying to lose weight. So the next issue of The Medical Letter (February 16, 2015), which will be devoted entirely to Diet, Drugs, and Surgery for Weight Loss, should be helpful in dealing with this common […]

Opioid Dependence

The next issue of The Medical Letter (February 2, 2015) includes an article on a new combination of the partial opioid agonist buprenorphine and the opioid antagonist naloxone for treatment of opioid dependence. The same 2 drugs are available generically and in 2 other brand name formulations for the same indication, which suggests that opioid […]

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