Timing Antiviral Treatment of COVID-19

The randomized, placebo-controlled, clinical trial of remdesivir sponsored by the National Institute of Allergy and Infectious Diseases (NIAID) in 1063 hospitalized patients with advanced COVID-19 and lung involvement began on February 21 and was closed to new enrollments on April 19. The results have not been published to date, but the NIAID reported in a […]

Problems with EpiPen Auto-Injectors

The FDA has alerted healthcare professionals and patients that various malfunctions can occur with EpiPen auto-injectors (Mylan) and their generic equivalents (Mylan, Teva). More specifically, the agency warned about: Device failure from spontaneous activation caused by using sideways force to remove the blue safety release. Device failure from inadvertent or spontaneous activation due to a […]

Remdesivir: A Possible Treatment for 2019 Novel Coronavirus

Notice: Due to rapidly changing information, the content of this blog may be obsolete. Please check our article, Some Drugs for COVID-19, and accompanying table, Treatments Considered for COVID-19, which are available free, for updated information. Every day our editors and expert consultants are sifting through the literature, checking government and society updates, and monitoring social media chatter, […]

Truth in TV Advertising: Empagliflozin (Jardiance)

Advertisements for prescription drugs are flooding our TV screens. I don’t think that’s a good thing, but are they untruthful (forbidden) or misleading (more difficult to police)? The long recitals of terrifying side effects add a note of caution, but since they come on so late and are intoned at such high speed, it may […]

Tafamidis (Vyndaqel; Vyndamax): Why Two Products?

Our website now hosts a free article about tafamidis, a new drug in the US approved for treatment of adults with transthyretin-mediated amyloid cardiomyopathy, a progressive, life-threatening, under-diagnosed disease often referred to by its acronym (ATTR-CM). The drug was approved in 2 formulations with different brand names and different doses, both manufactured by Pfizer. Vyndaqel […]

Before Vaccines

The current issue of The Medical Letter includes an article on this year’s influenza vaccine, which reminds me how crazy the world has become. The temperature went up to 108 degrees in Paris, and young women with PhDs are refusing to vaccinate their children, and not just against flu. Well, flu can be scary; the […]

A New Drug for Female Sexual Dysfunction

Ordinarily The Medical Letter does not review new drugs before their price becomes available, but the FDA’s approval of bremelanotide (Vyleesi) for treatment of female sexual dysfunction created so much interest that we felt obliged to break that rule. An article on Vyleesi will appear in our July 29 issue, which is available online now. […]