Coronavirus Vaccines

The Medical Letter’s online table of Treatments Considered for COVID-19 now includes a section on vaccines, neatly arranged by mechanism of action: adenovirus-vectored, mRNA, adjuvanted recombinant nanoparticle, and inactivated vaccines. Our list is incomplete, of course, because the number of vaccines now in clinical trials around the world is approaching 50, but we have included […]

So Many Drugs for Schizophrenia

Our next issue includes an article on lumateperone (Caplyta – Intracellular Therapies), a new oral treatment for schizophrenia. Lumateperone is the 13th second-generation drug for this indication, and there are 8 first-generation drugs still out there as well. Why are 21 drugs with more-or-less similar mechanisms of action being marketed for the same disease? One […]

Early Use of Remdesivir (Continued)

Two important communications turned up on my computer recently. First, two letters to the editor of The New England Journal of Medicine commenting on Beigel et al, Remdesivir for the Treatment of Covid-19 — Preliminary Report, published online on May 22 at NEJM.org. Both drew attention to the late introduction of remdesivir in the trial: […]

Timing Antiviral Treatment of COVID-19

The randomized, placebo-controlled, clinical trial of remdesivir sponsored by the National Institute of Allergy and Infectious Diseases (NIAID) in 1063 hospitalized patients with advanced COVID-19 and lung involvement began on February 21 and was closed to new enrollments on April 19. The results have not been published to date, but the NIAID reported in a […]

Problems with EpiPen Auto-Injectors

The FDA has alerted healthcare professionals and patients that various malfunctions can occur with EpiPen auto-injectors (Mylan) and their generic equivalents (Mylan, Teva). More specifically, the agency warned about: Device failure from spontaneous activation caused by using sideways force to remove the blue safety release. Device failure from inadvertent or spontaneous activation due to a […]

Remdesivir: A Possible Treatment for 2019 Novel Coronavirus

Notice: Due to rapidly changing information, the content of this blog post may be obsolete. Please check our article, Some Drugs for COVID-19, and accompanying table, Treatments Considered for COVID-19, which are available free, for updated information. Every day our editors and expert consultants are sifting through the literature, checking government and society updates, and monitoring […]

Truth in TV Advertising: Empagliflozin (Jardiance)

Advertisements for prescription drugs are flooding our TV screens. I don’t think that’s a good thing, but are they untruthful (forbidden) or misleading (more difficult to police)? The long recitals of terrifying side effects add a note of caution, but since they come on so late and are intoned at such high speed, it may […]