Mifepristone

The recent Supreme Court decision overturning Roe v. Wade has heightened interest in the use of the oral antiprogestin mifepristone (Mifeprex) for termination of intrauterine pregnancies. Mifepristone binds to progesterone receptors and increases prostaglandin levels by inhibiting prostaglandin dehydrogenase; both actions stimulate uterine contractility. It is generally used with the prostaglandin analog misoprostol (Cytotec, and […]

Overdose-Prevention Centers

The May 26 issue of The New England Journal of Medicine includes 2 articles on a subject that deserves more attention than it has received from us.1,2 Drug overdose deaths rose above 100,000 annually during the Covid-19 pandemic in the US, fueled at least partly by purposeful fentanyl contamination of illicit drugs. Naloxone is widely […]

AstraZeneca/Oxford COVID-19 Vaccine

An interim analysis of 4 randomized double-blind trials of an adenovirus-vectored COVID-19 vaccine was published recently.1 Developed through a partnership between AstraZeneca and Oxford University, this vaccine is relatively inexpensive and can be stored in standard refrigerators. It has been approved for use in the UK and several other countries, but not to date in […]

Vaccine Priorities

“Even the most privileged of humans in the Western world will join a tragically disfavored caste if they live long enough. They will belong to the last caste of the human cycle, that of old age, people who are among the most demeaned of all citizens in the Western world, where youth is worshipped to […]

Coronavirus Vaccines

The Medical Letter’s online table of Treatments Considered for COVID-19 now includes a section on vaccines, neatly arranged by mechanism of action: adenovirus-vectored, mRNA, adjuvanted recombinant nanoparticle, and inactivated vaccines. Our list is incomplete, of course, because the number of vaccines now in clinical trials around the world is approaching 50, but we have included […]

Early Use of Remdesivir (Continued)

Two important communications turned up on my computer recently. First, two letters to the editor of The New England Journal of Medicine commenting on Beigel et al, Remdesivir for the Treatment of Covid-19 — Preliminary Report, published online on May 22 at NEJM.org. Both drew attention to the late introduction of remdesivir in the trial: […]

Remdesivir: A Possible Treatment for 2019 Novel Coronavirus

Notice: Due to rapidly changing information, the content of this blog post may be obsolete. Please check our article, Some Drugs for COVID-19, and accompanying table, Treatments Considered for COVID-19, which are available free, for updated information. Every day our editors and expert consultants are sifting through the literature, checking government and society updates, and monitoring […]