When Will It All End?

That’s what my son asked me. What will it take for you to feel comfortable walking into a restaurant without a mask? Good question. I thought about it. A treatment, I said. An accessible, effective, oral treatment. Treatments that are approved or authorized by the FDA for COVID-19 include the antiviral drug remdesivir (Veklury), the  […]

Preview: Drugs for Chronic Heart Failure

The next issue of The Medical Letter will offer our readers an update on what’s new in the treatment of chronic heart failure, based largely on 2 other updates: the 2017 ACC/AHA/HFSA Focused Update of the 2013 ACC/AHA Guideline for the Management of Heart Failure and a 2021 ACC Update to the 2017 ACC Expert […]

Efficacy of Covid-19 Vaccines

Now that many of our patients have been vaccinated against Covid-19, they want to know if they could catch it anyway. The answer is yes, of course, but that does not mean that 5% of them will become infected, as some pundits have told them, if they received a 95% effective messenger RNA vaccine. The […]

Colchicine Past and Present

The anti-inflammatory drug colchicine has been used for many centuries to treat acute flares of gout. In more recent times, it has also been used for treatment of familial Mediterranean fever, various dermatologic conditions, pericarditis and now, reviewed on our website, coronary artery disease. Colchicine is found in the seeds, flowers and underground stems of […]

The Royal Road to Recovery from COVID

The president of the United States and the former governor of New Jersey sailed through their bouts with COVID-19. Both would be considered high-risk patients: the president because of his age and weight, and the governor because of his weight. According to newspaper reports, both were hospitalized, despite not having severe symptoms, and treated, first […]

Antivirals for Influenza

The upcoming issue of The Medical Letter leads off with an article on antiviral drugs for influenza, which could be considered an underused resource. Influenza isn’t COVID 19, but it often kills 30,000 people or more in a year, which is automobile accident and gunshot territory. Maybe this year widespread use of masks will limit […]

So Many Drugs for Schizophrenia

Our next issue includes an article on lumateperone (Caplyta – Intracellular Therapies), a new oral treatment for schizophrenia. Lumateperone is the 13th second-generation drug for this indication, and there are 8 first-generation drugs still out there as well. Why are 21 drugs with more-or-less similar mechanisms of action being marketed for the same disease? One […]