A Costly Cure for Hepatitis C

An article earlier this year in The Medical Letter (January 20, 2014) heralded FDA approval of the nucleotide polymerase inhibitor sofosbuvir (Sovaldi – Gilead) for use in combination with other antiviral drugs for treatment of chronic hepatitis C infection: “Sofosbuvir (Sovaldi) appears to be the most effective drug available to date for treatment of chronic […]

Chronic Lymphocytic Leukemia

The upcoming issue of The Medical Letter (April 14, 2014) includes an article on a promising new drug for chronic lymphocytic leukemia (CLL), which is the most common type of leukemia seen in the West. One of the reasons it is so common is that many patients with CLL live for decades, and did so […]

Aspirin Prophylaxis

A study published recently (March 31, 2014) in The New England Journal of Medicine found that patients who took daily aspirin (200 mg initially, then 100 mg) just before noncardiac surgery and continued it for 30 days (or 7 days before going back to a regular aspirin regimen) had a higher risk of major bleeding […]

Doxylamine/Pyridoxine for Nausea and Vomiting of Pregnancy

The March 20th issue of The New England Journal of Medicine includes an article from the Office of New Drugs of the FDA on a topic The Medical Letter reviewed in its August 5, 2013 issue: the FDA’s approval of Diclegis, a fixed-dose combination of the H1-antihistamine doxylamine and the vitamin B6 analog pyridoxine, for […]

Something Old, Something New

The next issue of The Medical Letter (March 31, 2014) includes 2 articles on new formulations of old drugs and one article on an old drug approved for a new indication. New drugs have to demonstrate efficacy and safety to be approved by the FDA, but there is no requirement in the law that they […]

Proton Pump Inhibitors

The next (April 2014) issue of Treatment Guidelines from The Medical Letter will be on Drugs for Peptic Ulcer Disease and GERD. Peptic ulcer disease is generally caused by NSAIDs, Helicobacter pylori infection, or both. GERD (gastroesophageal reflux disease) is thought to be the result of a loose esophageal sphincter or delayed gastric emptying. One […]


The next (March 17) issue of The Medical Letter will include a brief article on recent outbreaks of mumps in college students and other young adults. Mumps is transmitted by droplet or fomite exposure with an average incubation period of 16-18 days. The illness has a prodrome of headache, malaise, anorexia and fever, followed within […]


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